DMARDs-disease-modifying antirheumatic drugs (DMARDs)
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory arthritis that clinically manifests as joint pain, stiffness, and swelling. If left untreated, persistent synovial inflammation can progress to cartilage and bone destruction and ultimately to major long-term disability and mortality.
Synthetic disease-modifying antirheumatic drugs (DMARDs), such as
- methotrexate,
- leflunomide,
- sulfasalazine,
have markedly improved clinical symptoms and slowed joint damage in RA patients.
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